Must Style mode: the player must attain a S rank or higher in Style for being able to damage enemies;
Gods Must Die mode: a difficulty mode where enemies immediately spawn in Devil Trigger mode, and no items can be used nor can Green Orbs be gathered;
Turbo mode: increases the game speed in 20%;
Hardcore mode: emulates classic Devil May Cry series conventions: Devil Trigger no longer launches enemies when activated, gaining higher Style ranks is more difficult while your grade will decay faster, enemies deal more damage, and parrying requires more skill.;
new Blood Palace mode for Vergil;
new gameplay features such as a Manual Target Lock.