The game was originally planned to be released in 2004 by publisher The Adventure Company and developed by Jane Jensen's cofounded company Odyssey Digital Entertainment, Production of the game stalled over fears that big budget adventure games were no longer financially viable. The game was later picked up by dtp entertainment AG's publishing label ANACONDA in 2006 for a slated late 2007/early 2008 release. The game was to be developed by Tonuzaba Entertainment at first but then development moved over to Wizarbox, most likely because dtp wanted a more experienced adventure game development team on such a high profile release. This developer switch further delayed the game for a new planned release for sometime in 2009, with the game ultimately releasing in late 2010.
In her introduction found in the game manual, designer Jane Jensen recommends the following works for further exploring Gray Matter's subject matter: * The Man Who Mistook His Wife for a Hat (Oliver Sacks) * Phantoms in the Brain: Probing the Mysteries of the Human Mind (V.S. Ramachandran and Sandra Blakeslee) * The Conscious Universe: The Scientific Truth of Psychic Phenomena (Dean Radin)
Gray Matter 2 was an option from Jane Jensens Pinkerton Road Kickstarter campaign for a new Jane Jensen game (there were 3 options from which the backers could choose). However, the backers voted for the game Moebius instead. This also revealed what the game was to be about, The plot was going to be about David Styles and Samantha investigating the death of a young student with magical abilities.