Like its predecessor, Etherlords 2 is a turn-based strategy game, where the battle system is similar to collectible card games. The player the hero around an overland map, and when facing enemies a battle mode initiates. However, there is one big difference from the first game: the movement on the overland map is now performed in real-time.
In single-player mode it is possible to player either one duel or the entire campaign. There are four races available (Vitals, Kinets, Chaots and Synthets); unlike the previous game, each one of them has its own campaign. There is also a fifth campaign in which the player controls the mythical hero Diamanda.